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Your Location:Home > Medicinal mechanism of Thiourea

The following thiourea manufacturers to tell you about the medicinal mechanism thiourea:


   The basic role of thiourea is inhibition of thyroid peroxidase mediated by tyrosine iodination and coupling, while the drug itself is used as a substrate for peroxidase is iodide, iodine oxide not bound to thyroglobulin the protein, thereby inhibiting the biosynthesis of thyroid hormones. Thiourea drugs have been ineffective thyroid hormone synthesis, is subject to the synthesized hormone after being consumed to be fully effective. Usually medication 2 to 3 weeks began to ease symptoms of hyperthyroidism, 1 to 3 months basal metabolic rate returned to normal. After long-term use of this class of drugs, can serum thyroid hormone levels were significantly decreased, the feedback caused by increased TSH secretion glands compensatory hypertrophy, the gland increases, congestion, severe cases can produce symptoms of oppression.


Propylthiouracil can inhibit the conversion of T4 in peripheral tissues as T3, able to control the biological activity of serum T3 levels strong, so in severe hyperthyroidism, when the thyroid crisis can be classified as the drug of choice. In addition, there thiourea immunosuppression drugs can suppress mild immunoglobulin production, so that the blood circulation in thyroid stimulating immunoglobulin (thyroid stimulating immunoglobulin TSI) decrease, so in addition to patients with hyperthyroidism high metabolic control symptoms , etiology also have a therapeutic effect, because of that the incidence of autoimmune hyperthyroidism mechanism abnormalities.

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